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Metformin treatment throughout pregnancy in women with PCOS does not cause significant adverse effects such as fetal growth retardation or intrauterine death (Lautatzis et al., 2013)

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Inflammatory processes induce oxidative stress and mitochondrial dysfunction, which can exacerbate oxidative stress and trigger negative feedback that leads to downstream abnormalities in brain development and its dysfunction, leading to the pathogenesis of neurodevelopmental disorders such as ASD and ADHD [16,128,129]